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Reactive oxygen species (ROS) are oxygen-containing, chemically reactive molecules that are, under normal physiologic conditions, beneficial for optimal sperm functions such as the promotion of sperm capacitation, regulation of sperm maturation, and enhancement of cellular signaling pathways.[4] Nonetheless, at higher levels, ROS have been shown to induce lipid peroxidation (LPO), sperm DNA damage, and abortive apoptosis.[5] To overcome these unwanted events, excessive ROS are naturally stabilized or deactivated by the body's antioxidant system.[6] However, when excessive amounts of ROS are produced, or when the antioxidant system fails, a state of OS develops [Figures 1 and 2]