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Once a lead compound is found, the candidate has to be assessed in the preclinical stage to establish the safety and efficacy, including information about properties such as absorption, distribution, metabolization, and excretion, as well as the best dosage and administration route, and side effects/adverse events

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Accordingly, prior to considerations on the role of this important antioxidant system in the detoxification and/or metabolism of pro-oxidant molecules, it is important to mention that the proper maintenance of a physiological level of oxidant challenge, currently termed oxidative eustress, is essential for governing life processes through redox signaling [42, 43]

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