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for instance, a nanoparticle system incorporating an acid-cleavable polyethylene glycol (PEG) linker for the T7 peptide—which selectively binds to TfR receptors on the BBB—allows the acid-sensitive T7 to be cleaved from the nanoparticles within endo/lysosomes, supporting enhanced cellular uptake, rapid endo/lysosomal escape, and efficient transcytosis, ultimately improving in vivo distribution in AD mice (Cai et al., 2020)

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In: European Association of Psychology and Law (EAPL), 7-12 July 2003, Edinburgh