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Two other mechanisms were postulated by Esterbauer (1991) and consist in the successive generation of peroxydes and β-cleavage of the lipid chain or as a reaction of acroleine radical with a hydroxyl moiety (exemplification for arachidonic acid in Figure 4, adapted from Esterbauer, 1991)

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In pregnant women in The Gambia, for example, EGR AC values fell in association with a decline in body weight during the rainy season, despite evidence that malnutrition had actually increased (Bates et al., 1981)