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[DOI] [PubMed] [Google Scholar] 46.Rupnick MA, Panigrahy D, Zhang CY, Dallabrida SM, Lowell BB, Langer R, Folkman MJ

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How BPC-157 Reduces Inflammation: Potent but Site-Focused Repair BPC-157, when administered via distant systemic injection (such as subcutaneous in the abdomen), circulates throughout the body yet still produces pronounced localized reduction in inflammation at specific injury or damaged sites because its pleiotropic mechanisms—such as balancing nitric oxide signaling, upregulating VEGF and growth factors, downregulating pro-inflammatory cytokines (TNF-α, IL-6), and shifting macrophages from pro-inflammatory M1 to reparative M2 phenotypes—are context-dependent and preferentially engage in tissues under stress or injury, where repair pathways are already activated, effectively amplifying healing and resolving excessive inflammation precisely where needed without broadly suppressing it elsewhere