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Regularly, this occurs with increased levels of catecholamine (likely to occur in reperfusion), potentially leading to sudden cardiac death [69,70,71,72,73,74]
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Given the importance of GRK levels to morphine-dependent regulation of receptors in model cell systems, it is conceivable that alterations in GRK2 expression or subcellular distribution following chronic opioid treatment could contribute to significant reprogramming of opioid regulatory responses
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