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Pathway Effect Why it matters Broad gene modulation Up- or downregulates more than 4,000 human genes Nudges cells toward a younger, more regenerative expression profile Collagen & decorin synthesis Stimulates dermal fibroblasts at picomolar concentrations Rebuilds the supportive matrix that keeps skin firm and smooth NF-κB suppression Tones down the master inflammation switch Lowers cytokine and chemokine output in stressed tissue VEGF / angiogenesis Promotes new capillary growth in wound beds Delivers oxygen and nutrients to repairing tissue Antioxidant defence Raises glutathione, ascorbate and SOD in wound tissue Protects new tissue from oxidative damage during healing Copper delivery Acts as a safe shuttle for Cu(II) into cells at log K = 16.44 Supplies copper for cofactor-dependent repair enzymes without Fenton toxicity Deeper dive for scientific readers Pickart and colleagues (BioMed Research International, 2015) used broad-spectrum DNA microarrays to show that GHK-Cu modulates thousands of human genes, with particular enrichment in collagen, decorin, and glycosaminoglycan biosynthesis