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And here’s something that connects directly to gut health: research has found that glutathione levels are significantly lower in the inflamed intestinal tissue of people with inflammatory bowel disease — both ulcerative colitis and Crohn’s disease

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Because the PPPSPXS peptide is a GSK3 substrate itself, these studies raise the interesting possibility that this region of LRP6 directly competes with the N-terminus of β-catenin for LRP6 binding (i.e., “substrate competition model” of Wu et al., 2009)