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The introduction of a leucine zipper motif to quiescent cell proline dipeptidase (QPP), enabled QPP homodimerization, which is essential for QPP activation (Leung and Lassam, 1998) and tyrosine hydroxylase (Vrana et al., 1994) in which leucine zipper-induced protein dimerization showed a significant increase in enzymatic activity

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The samples that passed this quality assurance and QC step were then clustered with other expression data from similar and distinct tumour types to confirm expected expression patterns