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AMPK can phosphorylate a variety of transcription factors included in the energy metabolism and biogenesis pathways, providing necessary cellular mechanisms for skeletal muscle plasticity (50)
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Lastly, in a model of DSS-induced ulcerative colitis (UC), EC derived from grape seeds ameliorated intestinal inflammation by reducing TNF-, IL-6, NO, MPO, and MDA levels, while enhancing antioxidant enzyme activity (Zhang et al., 2016)
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