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This suggests that organophosphorus-induced formation of high-molecular-weight protein aggregates could be the missing link in the disruption of cellular function
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Unlike direct GPX4 inhibition, which remains difficult to deploy in vivo owing to bioavailability and systemic toxicity concerns, targeting enzymes that sustain the reduced CoQ 10 (CoQ 10 H 2 , ubiquinol) pool may provide a more tractable and context-selective strategy to lower the ferroptotic threshold in tumors
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