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Posttranslational modifications (PTMs) are widely found in eukaryotic cells
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In the dietary obese mice, the elevation of hepatic microRNA-34a (miR-34a) inhibited the expression of NAMPT and SIRT1, which was responsible for the decrease in NAD+ levels and SIRT1 activity ( Because of the high intake of dietary sugar, the risk of metabolic syndrome and T2D has been on the increase in humans (Malik et al., 2010)
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