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Two-dimensional oxyblots and mass spectrometry-based protein fingerprinting identified GS as a specific target of oxidation
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The nephrotoxicity was blocked by the GGT inhibitor AT-125 ((l-αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid) and by aminooxyacetate (AOA), indicating the involvement of GGT and a cysteine S -conjugate β-lyase, respectively, in the nephrotoxicity of hexachlorobutadiene S -conjugates (Schrenk et al., 1988a
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