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The standard approach for a patient reporting side effects is: First-dose effects: reassure, continue protocol, expect adaptation by dose 3-4 Persistent nausea: switch injection timing to evening with food Injection-site reactions beyond 48 hours: evaluate for preservative sensitivity, consider formulation change Recurrent bruising: review injection technique, consider switching to 31-gauge needle This is pattern recognition, not a randomized trial, but it reflects real-world clinical decision-making across hundreds of patient-months of treatment
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