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DOI: 10.1093/eurheartj/ehr158 89
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Oxyhemoglobin suffers autoxidation daily (2–3%), with oxidation of heme ferrous iron into ferric iron [10], leading to the formation of methemoglobin (metHb), which is not capable of O 2 transport, and the release of superoxide anion that is converted to H 2 O 2 , with a lower oxidant capacity [11]
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