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Upon presentation, additional laboratory studies are necessary to obtain other important clinical parameters, including arterial blood gas (to investigate acid/base status), coagulation profile, basic metabolic panel, hepatic function tests, and urine drug screen (to determine possible co-ingestions)

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FIGURE 3 3.3 Potential mechanisms of DOR inhibition on tau phosphorylation CDK5 and GSK3β are two main kinases responsible for tau hyperphosphorylation (Figure 4)