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The primary S source is sulfate, which, following uptake by specific transporters, is reduced and incorporated into the amino acids Cysteine (Cys) and Methionine, and thereafter into proteins and peptides, including the multifunctional tripeptide thiol glutathione (Takahashi et al., 2011)

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The researchers surmised that the typical reduction of glutathione in the elderly was due to a lower supply of glycine and cysteine, the precursors to glutathione synthesis, and that upon supplementation, they had the ability to stimulate synthesis and restore levels