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However, subtle but important differences in the precise processes modulated might provide some discriminating value: for instance, dopamine has an established role in reinforcement learning in response to rewards [28,29], whereas serotonin seems to modulate reinforcement learning for aversive stimuli [20,23]

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See ”Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death” and “To inhibit TrxR1 is to inactivate STAT3-Inhibition of TrxR1 enzymatic function by STAT3 small molecule inhibitors” for further information