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doi: 10.1016/j.msec.2019.110083 [DOI] [PubMed] [Google Scholar] 275

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CJC-1295 with and without DAC Tesamorelin: visceral adipose tissue and hepatic steatosis endpoints, its HIV-lipodystrophy approved indication, and the cognitive endpoints under study ALRN-5281 and stapled long-acting GHRH analogs in early clinical study Ipamorelin, GHRP-2, GHRP-6, hexarelin: selectivity, cortisol and prolactin effects Ghrelin, macimorelin and anamorelin: appetite, cachexia and diagnostic applications MK-677 as an orally active non-peptide secretagogue and its distinct risk profile Combination logic (GHRH analog plus ghrelin agonist) and the evidence behind stacking IGF-1 monitoring intervals, target ranges and stopping rules 4.3Anabolic Signaling, Myostatin & SARMs Context IGF-1 and IGF-1 LR3: receptor affinity, binding-protein evasion and hypoglycemia risk MGF and PEG-MGF: the mechano-sensitive IGF-1 splice variant and its evidence tier Myostatin and activin signaling: follistatin-344 and ACE-031 as investigational probes SARMs — the science, the trial history and the controversy, taught as non-peptide context Adverse events reported with SARM use: hepatotoxicity, lipid changes, HPG-axis suppression Contaminated and mislabeled "research" product analyses in the published literature Counseling the patient who arrives already using an unsupervised anabolic protocol 4.4Athletes, Anti-Doping and Performance Ethics WADA Prohibited List structure: S2 peptide hormones and growth factors, S1 anabolic agents, S0 non-approved substances Which agents in this program are prohibited in and out of competition Therapeutic Use Exemptions: eligibility, documentation and realistic likelihood Collegiate, professional-league and military testing programs and how they differ from WADA Testing methodology basics: isoform tests, biomarker panels, biological passport concepts The clinician's documentation duty when treating a tested athlete Declining to prescribe: how that conversation is conducted and recorded Module 5 · 5 lessons · 36 topics Regenerative, Musculoskeletal & Organ Repair The repair cascade end to end: the core reparative peptides, the connective-tissue and bone agents, the organ-directed bioregulators, and the procedural modalities they are combined with