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List of Abbreviations: 2-OG 2 ‒ 2-oxoglutarate Acivicin or Aci L-(αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid AOAA aminooxyacetic acid BBM brush-border plasma membrane BLM basolateral plasma membrane BSO L-buthionine-S,R-sulfoximine CCBL cysteine conjugate β-lyase CDDP cisplatin CYP cytochrome P450 DCVC S -(1,2-dichlorovinyl)-L-cysteine DCVG S -(1,2-dichlorovinyl)glutathione DIC dicarboxylate carrier DMS dimethylsuccinate FMO flavin-containing monooxygenase γ-GluGlu L-γ-glutamyl-L-glutamate GGT γ-glutamyltransferase GPX glutathione peroxidase GSH glutathione GSSG glutathione disulfide GST glutathione S -transferase MRP multidrug resistance protein MVK methyl vinyl ketone NAC N -acetyl-L-cysteine NaC3 sodium-dicarboxylate carrier 3 NPX uninephrectomy OAT organic anion transporter OATP organic anion transporting polypeptide OGC oxoglutarate carrier PAH p -aminohippurate PBPK physiologically-based pharmacokinetic PT proximal tubular rDT rat distal tubular rPT rat proximal tubular ROS reactive oxygen species tBH tert -butyl hydroperoxide TCE trichloroethylene Footnotes Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication