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What's the difference between NIOD CAIL vs. CAIS | NIOD
AEDG core as a tool to study pharmacological modulation of the Hayflick limit Chronobiology and the pineal-hypothalamic axis — melatonin secretion profile, expression of circadian clock genes (Bmal1, Per, Cry), models of rhythm desynchronization in aging Geroprotection in rodent models — survival parameters, oxidative stress markers, incidence of cancer in long-term cohorts (Anisimov’s line of research) Profile “peptide geroprotectors” — comparison with other short regulatory peptides of the bioregulation school in terms of their impact on aging markers Summary N-Acetyl Epithalon (Ac-Ala-Glu-Asp-Gly) is an acetylated variant of the native tetrapeptide Epithalon (AEDG) – a core sequence developed by Vladimir Chawinson as a standardized analog of pineal epithalamine, additionally stabilized by an acetyl group at the N-terminus
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