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Notably, N-acetylcysteine (NAC), the clinical antidote, restores GSH but does not directly suppress iron-dependent lipid peroxidation, which may explain why ferroptosis inhibitors confer additional hepatoprotection in preclinical models [193], [194], [195]
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Together, our data suggest that there is significant cross talk between the injured kidney and the liver during ischemic AKI
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