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Furthermore, ATZ and its metabolites, DEA and DIA, all underwent glutathione (GSH) conjugation in human liver microsomes and human liver S9 fractions (66)
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This pathway can be triggered through two major signaling routes: the extrinsic pathway is initiated when extracellular ligands are bound to the death receptor's extracellular domain, forming a death-inducing signaling complex (DISC) consisting of the adaptor molecule, procaspase-8 and procaspase-10
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