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However, in the U.S., areas with the highest PHD scores had a 13% reduction in irrigation water demand compared to areas with the lowest PHD scores [78], consistent with findings from the Iranian study [46]

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Interestingly, some JAK2-activating mutations including V617F have been shown to require interaction with a cytokine receptor for their activity, suggesting that these mutations only disrupt inhibition of the pseudokinase when the JAK2 is bound to a receptor (90–93)

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