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Currently, oral tolerance has been applied to autoimmunity and inflammatory diseases such as peanut allergy [40, 41], allergic asthma [42, 43], pollen allergy [44], nonalcoholic steatohepatitis (NASH) [45], Pompe disease [46], rheumatoid arthritis [47, 48], type I diabetes [49, 50], hemophilia A and B [51–54] in preclinical as well as clinical studies

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Epithalon is a synthetic peptide composed of four amino acids (Ala-Glu-Asp-Gly), formally known as a “tetrapeptide.” It was developed in the 1980s by researchers at the St