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Cortical glutamatergic and GABAergic neurons, the major excitatory and inhibitory neuronal cell types, respectively, are depleted of mCG in and around the transcription starting sites (TSS) of genes with cell type-specific functions

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For instance, low blood calcium not only causes spasms in the muscles of the hands and wrists and jaw, but it can also cause a sensation of numbness and tingling around the mouth and other areas