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For example, in particulate matter exposure-related models, GLS1-mediated enhancement of glutaminolysis, together with alterations in local Gln/α-KG levels, can be accompanied by enhanced M1-like polarization, and inhibition of GLS1 can alleviate this pro-inflammatory polarization trend (60)
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This depth of human trial evidence provides greater confidence in safety characterization compared to peptides with primarily theoretical or animal-based safety data
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