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Elevated L-lactate levels beyond this physiological range lead to hyperlactatemia, which is often triggered by various pathological processes are associated with deficient mitochondrial adenosine triphosphate (ATP) production (e.g., hypoxia), increased aerobic glycolysis (e.g., the Warburg effect, diabetic acidosis), or decreased lactate removal (9)

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In conclusion, this review suggests that the simplistic notion that MDD is caused by reduced GABA neurotransmission must be discarded in favor of a more nuanced and complex model of the role of inhibitory neurotransmission in MDD