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The progressive form of AD can be caused by cerebral disorders, intoxication, infection, and defects in the pulmonary and circulatory systems, leading to reduced oxygen supply to the brain, by nutrient and vitamin B12 deficiency, as well as by tumors [5, 6, 7, 8]

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REDEFINE is an ongoing phase 3 trial acting as market evaluation for both CagriSema and cagrilintide, with 60% randomised to CagriSema, 10% cagrilintide, 10% semaglutide, and 20% placebo, where minimum age at inclusion was 55 years with no upper limit [117]