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Succinimide formation is considered to be caused by nucleophilic attack of the amide nitrogen of the ( N + 1) residue to the amide carbon of the Asn side chain, and proceeds via the tetrahedral intermediate that includes gem -hydroxylamine (Figure 2)
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Immune-glia interactions contribute to demyelination and failed remyelination in MS Myelin is a lipoprotein sheath produced by oligodendrocytes (OLs) which wraps axons, speeding conduction and providing metabolic and trophic support to neurons
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