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Others showed that accumulation of Aβ-induced oxidative stress in APOE4 leads to the deregulation of the TP53 gene, and in addition to its role in cancer p53 protein (encoded by a TP53 gene) can be involved in cell death in AD patients, with upregulation at the early stages of the disease and downregulation during neurodegeneration (445)

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Preliminary clinical evidence suggests that B12, particularly subcutaneously injected mB12, improves metabolic abnormalities in ASD along with clinical symptoms