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Studies have demonstrated that VNS shifts macrophage from proinflammatory M1 phenotype to an anti‐inflammatory M2 phenotype, contributing to reduced renal inflammation and injury (Inoue et al

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Using the clinical data of four patients, they observed an inverse correlation of the amount of glutathione and COVID-19 severity in patients where severe cases had significantly low endogenous glutathione levels, higher ROS, and a higher ROS/glutathione ratio in plasma than patients with mild disease [102]