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And CD4 + CD25 + T cells effectively inhibited colonic effector T cell activity and the production of Th1 (interferon (IFN)-Ξ³, IL-2) and Th2 (IL-5, IL-13) cytokines in vitro, while the frequency of Treg cells in the inflammatory area increases with the increase of active UC disease activity [68, 69]
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The overall experimental design of this study is illustrated in Fig
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