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GDF8, expressed predominantly in skeletal muscle, is cleaved by all TLDs and preferentially by TLL2 due to the availability of this TLD in the muscle, while the ubiquitously expressed GDF11 is cleaved preferentially by BMP1 and TLL1 [6]
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Responses to emotional changes and reward stimuli are dependent on intact function of the salience network , within which the anterior insula, anterior cingulate cortex and amygdala, ventral tegmental area, and thalamus function together to segregate the most relevant and rewarding among internal and extra-personal stimuli in order to guide behavior
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