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In general, given the distinctive effects of NO-agents L-NAME and/or L-arginine in the eye studies (i.e., retinal ischemia, pupil control, corneal anesthesia) [12,13,17], few distinctive NO-pathways might be correspondingly presented [96,97]
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Evidence suggests that this hypertensive response may serve as a pharmacodynamic biomarker of effective VEGF pathway inhibition
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