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Although vaccine-elicited antibodies neutralized more recent VoCs such as Omicron quite poorly relative to ancestral SARS-CoV-2, significant binding of vaccine-elicited antibodies to Omicron full-length spike protein was preserved, suggesting the maintenance of conserved spike epitopes recognized by non-neutralizing antibodies capable of FcR activation 107

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For example, CAP suppressed the stemness of triple-negative breast cancer cells via modulating AQP3-mediated AQP3-5 K and FOXO1 K48-ubiquitination, where H 2 O 2 entry through AQP3 for signal relay played a significant role [266] (Fig