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NOT a peptide, with no amino acid chain of any kind Component 1 — molecular target An inhibitor of the enzyme NNMT (nicotinamide N-methyltransferase), a cytosolic SAM-dependent enzyme Component 1 — selectivity Does not inhibit structurally related SAM-dependent methyltransferases nor the enzymes of the NAD+ salvage pathway (Neelakantan et al., 2017) Component 1 — membrane permeability Characterized as permeable in PAMPA and Caco-2 cell assays — both passive and active transport (Neelakantan et al., 2017) Component 2 — class NAD+ (nicotinamide adenine dinucleotide): a naturally occurring coenzyme, a dinucleotide
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