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This theory would involve recognizing the existence of a GPI-PLC whose gene has not been identified in mammals, in addition to assuming that cholesterol microdomains are present in all cell types where insulin activity is shown, and this does not explain why IPGs may allosterically modulate intracellular elements of the insulin pathway

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Clinical trials are needed to assess the safety and efficacy of these approaches in humans and to determine their potential to halt or reverse the DKD progression