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Polymorphism of MTHFR and Its Relationship with Hyperhomocysteinemia, Oxidative Stress, and Lipoprotein Modification The C677T polymorphism of the MTHFR gene results in a 50–60% reduction in enzyme activity [143]
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To confirm their role in clinical research, we searched the Clinical Trial Database ( using the keyword "Intranasal Drug AND Mitochondria AND Brain Injury AND CNS Disease", which revealed zero results, confirming that none of these compounds have been tested clinically employing the intranasal route of drug delivery
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