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Inhibition of copper chaperones sensitizes human and canine osteosarcoma cells to carboplatin chemotherapy

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[176] In some embodiments, administration of one of the novel anti-pro/latent-myostatin antibodies or antigenbinding fragments thereof disclosed herein in conjunction with a standard-of-care treatment for diabetes and/or obesity (e.g., a GLP-1 pathway activator, e.g., semaglutide, tirzepatide, AMG-133 (a GLP-1 receptor agonist/GIP- 1 receptor antagonist being developed by Amgen), or danuglipron (an oral GLP-1 receptor agonist being developed by Pfizer)) can result in greater efficacy than administration of the standard-of-care treatment alone