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The only interventions with any human evidence for modifying celiac disease beyond diet include larazotide acetate, a tight-junction regulator studied in phase 2 trials (Kelly et al., 2013, Alimentary Pharmacology and Therapeutics), and oral enzyme therapies like ALV003, shown in a 6-week trial to reduce gluten-induced mucosal injury by approximately 70% (Tye-Din et al., 2010, Science Translational Medicine)
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