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To restore NAD + levels, ATM-deficient models were treated with NR, which stimulated PINK1-dependent mitophagy, reduced cytoplasmic DNA levels, and activated the NAD + -dependent SIRT1 signaling pathway, which in turn further promoted mitochondrial mitophagy and healthy morphology 111,288
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Size:10 Grams (0.4 oz)
doi: 10.1016/j.jid.2022.06.018 108 AustermannJZenkerSRothJ
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