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PO 2 is significantly lower in the outer cortical proximal and distal convoluted tubules but not in the efferent arterioles of SHR when compared with normotensive Wistar Kyoto (WKY) rats 52
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[4] NAD+ can be produced in the body by biosynthetic intermediates such nicotinamide mononucleotide and nicotinamide riboside as well as by the amino acid tryptophan or the vitamin precursors nicotinic acid and nicotinamide, generally known as vitamin B3 or niacin
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