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A 2021 meta-analysis covering 14 trials found that antioxidant interventions including NAC and alpha-lipoic acid (which regenerates glutathione) reduced albuminuria by 18–25% in early-stage diabetic kidney disease
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As reference, we also measured the expression of spxB (encodes for the pyruvate oxidase) [32, 33] and sodA (encodes for a superoxide dismutase) [6] that increased their transcript levels in response to H 2 O 2 , as reported for aerobic conditions [5]
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