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According to a large meta-analysis of 166,682 subjects in total, the pooled risk of CVD events in PCOS women demonstrated a OR of 1.66 (95% CI: 1.32–2.08), and the risks of myocardial infarction (OR: 2.57, 95% CI: 1.37–4.82), ischemic heart disease (OR: 2.77, 95% CI: 2.12–3.61), and stroke (OR: 1.96, 95% CI: 1.56–2.47) were higher in the PCOS group, showing an overall increased risk of CVD events among PCOS patients [86]