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Experimental data suggest that quercetin concentrations exceeding 20 µM generally decrease melanin production, while concentrations between 10 and 20 µM may increase melanin content

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The renal clearances of hydrochlorothiazide and the pharmacologically active metabolite of triamterene, the sulfate ester of hydroxytriamterene, have been shown to be reduced and the plasma levels increased following triamterene and hydrochlorothiazide administration to elderly patients and patients with impaired renal function