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Considering many of these facts, it is probably beneficial to increase plasma vitamin B12 and homocysteine levels owing to their close affiliation with carotid intima-media thickness [3]

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The disease should be suspected in such presentation and should be treated as early as possible despite normal serum cobalamin levels may appear normal, as holoTC represents only about 20% of total cobalamin, while elevated levels of MMA and tHcy in blood and urine are indicative of the condition, the diagnosis of TC II deficiency is need to be confirmed by genetic analysis.14 Interestingly, The N-terminal region of the TC receptor CD320 (also known as TCblR/CD320) serves as a binding site for HoloTC