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Conclusion: Integrated multiomics analyses showed perturbations in skeletal muscle mitochondrial function and structure with stabilization of HIF1a and myostatin Disclosures: Nicole Welch: Nothing to Disclose, Pugazhendhi Kannan: Nothing to Disclose, Saurabh Mishra: Nothing to Disclose, Annette Bellar: Nothing to Disclose, Laura Nagy: Nothing to Disclose, Srinivasan Dasarathy: Nothing to Disclose 1481 THE ROLE OF PSYCHOTHERAPY ALONE IN REDUCING ALCOHOL RETURN TO DRINKING IN PATIENTS WITH CHRONIC LIVER DISEASES: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS Christopher Sollenberger 1 Huai-En Chang 1 Mohammed Rifat Shaik 2 Hanna Blaney 1 Nancy Terry 3 Nancy Diazgranados 4 Christine Hsu 1 , 1 National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA, 2 University of Maryland Medical Center Midtown Campus, Baltimore, MD, USA, 3 National Institutes of Health Library, Bethesda, MD, USA, 4 National Institute of Alcohol Abuse and Alcoholism, Bethesda, MD, USA Background: Psychosocial interventions are effective in alcohol cessation, but many studies are conducted on alcohol use disorder (AUD) patients