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Link to the announcement: #Type2Diabetes #Obesity #GLP1 #Semaglutide #Amylin #Cagrilintide #CagriSema #ClinicalTrials #Diabetology #MetabolicHealth Paramesh Shamanna Impressive data, but real impact will depend on long-term safety, adherence, and how thoughtfully we pair drugs with lifestyle foundations.

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A 28-day, phase 1 MAD trial results in dose-dependent mean body weight reductions of 2.5%, 3.7%, 4.1%, 7.4%, and 7.8% at target doses of 0.5 mg, 1.5 mg, 5.0 mg, 7.5 mg, and 10 mg, respectively, compared to 1.8% for the placebo group (65)