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0.14 ± 0.04 µM, respectively) and significantly higher potency than ibrutinib ( 11 , IC 50 = 0.94 ± 0.27 µM) 68
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Furthermore, perturbations in the uptake and homeostasis of B vitamins, which results in deficiency or excess of one-carbon metabolism intermediates, can lead to neurological defects, anemia, aberrant immune responses, and cancer [8,9,10]
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